Review date: May 2026
Overview
Florylpicoxamid (Adavelt™ Active) is a broad-spectrum fungicide first registered by the U.S. Environmental Protection Agency (EPA) in June 2025.
The MDA routinely conducts reviews of new pesticide active ingredients (a.i.) before registration in Minnesota. The MDA completed its review of florylpicoxamid in May 2026 and did not identify any risks of concern specific to Minnesota. To evaluate the potential impacts of florylpicoxamid on groundwater and surface water, the MDA may add this a.i. to its water quality monitoring program. Florylpicoxamid is a per-/polyfluoroalkyl substance (PFAS) based on Minnesota’s PFAS definition (MINN. STAT. 18B.01, subd. 15c). Therefore, products containing florylpicoxamid will be subject to additional regulations under the Pesticide Control law.
The following is a summary of the MDA’s review of the EPA’s florylpicoxamid risk assessments and product labels (EPA Docket EPA-HQ-OPP-2020-0449). The EPA uses high-end, conservative exposure estimates to evaluate risk based on various use scenarios. As a result, exposure estimates may not reflect future use and impacts in Minnesota.
Active Ingredient Details
- Chemical Abstracts Service (CAS) Number: 1961312-55-9
- EPA Pesticide Chemical Code: 119032
- Chemical class: Picolinamide
- Mode of Action (Fungicide Resistance Action Committee): Group 21 - Quinone Inside Inhibitors (Qil)
- Basic Manufacturer: Corteva Agriscience, LLC
Use Profile
Use Sites
Florylpicoxamid is registered for agricultural use on barley, canola, dried shelled pea and bean (except soybean), sugar beet, and wheat, and non-agricultural use on established turfgrass on golf course tees, greens, and fairways.
Target Pests
Fungal diseases targeted by florylpicoxamid include anthracnose (Colletotrichum spp.), powdery mildew (Erysiphe betae), dollar spot (Clarireedia spp.), white mold/stem rot (Sclerotinia sclerotiorum), and Cercospora leaf spot (Cercospora beticola), among others.
Application Rates and Methods
Post-emergent foliar applications of florylpicoxamid can be made to agricultural sites via aerial, ground, or chemigation equipment. Applications to turfgrass can be made via ground boom and handheld equipment. Maximum single and maximum annual application rates vary by use site.
Table 1. Maximum application rates for select use sites
| Use Site | Max Single Rate (lb a.i./acre) | Max Annual Rate (lb a.i./acre/year) |
|---|---|---|
| Ag | 0.134 | 0.268 |
| Turf | 0.134 | 0.450 |
Products
The EPA has registered three end-use products and one technical product containing florylpicoxamid. Product trade names include GF-3840 Ag, GF-3840 Turf, Verpixo™ and Adavelt Technical. Go to the Kelly Solutions registered pesticide product database to view a list of florylpicoxamid products registered for use in Minnesota.
Projected Use in Minnesota
Florylpicoxamid may be a valuable fungicide for a variety of Minnesota crops and aid in resistance management. For example, trials by University of Minnesota Extension on sugar beet for Cercospora beticola demonstrated a high level of efficacy, and florylpicoxamid will be a useful tool in integrated disease management for rotating modes of action and managing disease resistance.
Human Health
Toxicity Profile
- Signal Word: Warning
- Toxicity Category (Based on acute exposure): Category III (low toxicity) via oral and dermal routes; Category IV (very low toxicity) for inhalation, eye and skin irritation
- Population-Adjusted Dose (PDA) for Dietary Exposure: Acute PAD not calculated – No acute dietary endpoint attributable to a single dose identified Chronic PAD = 0.1 mg/kg/day
- Cancer Classification: "Not likely to be carcinogenic to humans."
Drinking Water
The EPA identified the parent compound, florylpicoxamid, and three of its degradates (X12485649, X12485631, and X12485473) as residues of concern for drinking water. The highest estimated drinking water concentrations in groundwater for florylpicoxamid + X12485649 + X12485631 + X12485473 were 318 µg/L and 212 µg/L for acute and chronic exposure, respectively. No chronic dietary (food and drinking water) risks were identified by the EPA. An acute dietary assessment was not conducted because no appropriate acute endpoints were observed.
Occupational and Residential Exposure
The EPA concluded there are no occupational handler and post-application noncancer dermal or inhalation risks of concern, and no residential post-application dermal risks of concern.
Environmental Fate
The movement and breakdown of florylpicoxamid in the environment can vary depending on numerous factors, including application site and methods, soil type, and weather. It is classified as slightly to moderately mobile in soil. It is non-persistent and degrades quickly in the environment. It may be transported to surface water via spray drift, runoff, and erosion but has limited potential to leach to groundwater.
Table 2. Florylpicoxamid properties
| Pesticide Property | Value |
|---|---|
| Solubility in Water (20°C) | 3.0 to 4.0 mg/L Moderately soluble |
| Vapor Pressure (20°C) | <3.5 x 10-8 torr Non-volatile under field conditions |
| Henry's Law Constant (20°C) | 5.9 × 10-9 atm-m3 mol–1 |
| Binding Affinity/Sorption | Koc = 528 to 3,311 L/kgoc Slightly to moderately mobile |
| Octanol-Water Partition Coefficient | log Kow=4.2 |
Table 3. Florypicoxamid dissipation rates
| Degradation Study Type | Dissipation Rate [DT50] |
|---|---|
| Abiotic Hydrolysis | pH 4: 12.7 days; pH 7: 16.7 days; pH 9: 0.4 days |
| Aqueous Photolysis | 0.3 days |
| Soil Photolysis | 177 days |
| Aerobic Soil Metabolism | 0.4 to 1.2 days |
| Anaerobic Soil Metabolism | 0.8 to 3.8 days |
| Aerobic Aquatic Metabolism | 0.1 days |
| Anaerobic Aquatic Metabolism | 0.5 to 2.5 days |
| Terrestrial/Field Dissipation | <1 to 7 days |
Degradates
Florylpicoxamid has at least seven major degradates. The primary degradate, X12485649, is more persistent than the parent florylpicoxamid, with half-lives of 166 to 1,499 days in soil and 176 to 202 days in water. X12485649 is slightly to hardly mobile in soil (Koc 1,490 to 22,736 L/kgoc).
Ecotoxicology
Risk Assessment and Residues of Concern
The EPA uses the Risk Quotient (RQ) Method to evaluate potential ecological risks from pesticides. The RQ is calculated by dividing the estimated environmental exposure concentration of a chemical by its toxicity endpoint. RQ values are then compared to established Levels of Concern (LOCs). RQ values above the LOC indicate a potential risk and need for further assessment or mitigation measures.
Residues of concern for EPA’s ecological risk assessment include florylpicoxamid and its X12485649 degradate. X12485649 has similar toxicity as florylpicoxamid to aquatic organisms, whereas degradates X12485473, X12485631, and X12719657 are less toxic than the parent. While no studies are available on the toxicity of X12485649 to terrestrial organisms, the EPA assumes it is similar in toxicity to the parent.
Aquatic Ecotoxicology and Risk
Table 4. Florypicoxamid aquatic toxicity. LC50 = Lethal Concentration 50%; NOAEC=No Observable Adverse Effect Concentration; IC50 = Inhibition Concentration 50%.
| Taxa | Toxicity Value | Acute Risk Category |
|---|---|---|
| Freshwater Fish (Surrogates for Aquatic-Phase Amphibians) | Acute: 96-hr LC50 = 11.1 μg a.i./L Chronic: NOAEC = 3.44 μg a.i./L | Very Highly Toxic |
| Freshwater Invertebrates (Water-Column Exposure) | Acute: 48-hr LC50 = 59.8 μg a.i./L Chronic: NOAEC= 7.23 μg a.i./L | Very Highly Toxic |
| Aquatic Non-Vascular Plants | IC50 = 271 μg a.i./L | - |
| Aquatic Vascular Plants | IC50 = 1,090 μg a.i./L | - |
In its ecological risk assessment, the EPA determined that RQs exceeded the regulatory LOC for non-listed species for freshwater fish and aquatic-phase amphibians (in small waterbodies only) and freshwater invertebrates. To mitigate these risks, the registrant limited or removed certain turf use sites, reduced the maximum annual application rate for turf, and reduced annual aerial applications for all agricultural uses except sugar beets from two applications to one. The RQs were below the non-listed LOC for aquatic and wetland plants.
Terrestrial Excotoxicology and Risk
Table 5. Florypicoxamid terrestrial toxicity. LD50 = Lethal Concentration 50%; NOAEL=No Observable Adverse Effect Level; NOAEC=No Observable Adverse Effect Concentration; TEP = Typical end-use product.
| Taxa | Toxicity Value | Acute Risk Category |
|---|---|---|
| Mammals | Acute: LD50 > 2,000 mg a.i./kg bw (rat) Chronic: NOAEL = 222 mg a.i./kg bw (dog) | Practically Non-toxic |
| Birds | Acute: LD50 > 2,000 mg a.i./kg bw Chronic: NOAEC = 392 mg a.i./kg diet | Practically Non-toxic |
| Terrestrial Invertebrates - Bees | Acute: Chronic: | Practically Non-toxic |
| Terrestrial Plants | Seedling emergence: NOAEC = 0.067 lb a.i./A (TEP) Vegetative vigor: NOAEC = 0.067 lb a.i./A (TEP) | - |
The RQs exceeded the regulatory LOC for non-listed species for terrestrial invertebrates and terrestrial plants (when used on sugar beet only). The RQs are below the LOC for non-listed birds, reptiles, terrestrial-phase amphibians, and mammals.
Mitigations for RQ exceedances included removing some use sites for turf, lowering turf application rates, and reducing aerial applications from two to one on all agricultural uses except sugar beets.
Listed Species
The EPA conducts a Biological Evaluation to assess whether a pesticide may affect any federally listed species or critical habitat. In its final effects determination, the EPA concluded that the proposed uses of florylpicoxamid were likely to adversely affect multiple listed species and critical habitats. The EPA implemented mitigations to address the potential likelihood of future jeopardy for two listed species (Casey’s June beetle and rusty patch bumble bee) and the likelihood of adverse modification for the critical habitats of seven listed species. Mitigations include the development of Pesticide Use Limitation Areas (PULAs) with date restrictions on golf course applications and restrictions on applications to peas, beans, and canola before and during flowering growth stages. Currently, the only Minnesota relevant PULA applies to applications on peas, beans, and canola within the range of the rusty patched bumble bee and states: “Do not apply florylpicoxamid within this area within three days prior to bloom, during bloom, and until petal fall is complete.”
Product Labels
The following hazard warnings or use restrictions appear on at least one end-use product but may not appear on all products. Always read and follow the label for the specific product you are applying. For additional information on product labeling criteria, see the EPA’s Label Review Manual.
Environmental Hazards
Surface Water Advisory
Florylpicoxamid may impact surface water quality due to runoff of rainwater. This is especially true for poorly draining soils and soils with shallow ground water. A level, well-maintained vegetative buffer strip between areas to which florylpicoxamid is applied and surface water features such as ponds, streams, and springs will reduce the potential loading of florylpicoxamid from runoff water and sediment. Runoff of florylpicoxamid will be reduced by avoiding applications when rainfall or irrigation is expected to occur within 48 hours.
Mandatory Spray Drift Management Mitigations
Applicators must comply with spray drift requirements on the label for aerial and ground boom applications. Users must follow requirements for wind speed, nozzle and pressure, wind speed and direction documentation, temperature inversion guidance, and boom height and location.
Endangered and Threatened Species Protection Requirements
Before using this product, you must obtain any applicable Endangered Species Protection Bulletins (Bulletins) within six months prior to or on the day of application. To obtain Bulletins, go to the EPA's Bulletins Live! Two. When using this product, you must follow all directions and restrictions contained in any applicable Bulletin(s) for the area where you are applying the product, including any restrictions on application timing if applicable. It is a violation of Federal law to use this product in a manner inconsistent with its labeling, including this labeling instruction to follow all directions and restrictions contained in any applicable Bulletin(s).
Date Posted: August 24, 2026
